Power of genomics :
Scientists net new culprits for cancer
Combining the number-crunching potency of computers with an
exploration of the genetic code, scientists said on Sunday they had
identified a new master gene in cancer as well as faulty genes
implicated in breast and skin tumours.
The research, published by separate teams in the journal Nature
Genetics, could open up avenues to identify people at risk and,
potentially, new drugs to block the mechanisms that let cancers
proliferate, they hope.
British-based researchers said a gene called UTX, found in the X
gender chromosome, played the role of ringmaster in 10 percent of cases
of multiple myeloma and one in 12 cancers of the oesophagus.
UTX controls an enzyme that contributes to the structure of DNA in
our cells. The enzyme also acts as a switch, turning other genes on and
off.
In a massive genetic trawl through tissue samples from patients with
a form of kidney cancer, the scientists found a rare but telling
signature among a mutated form of UTX.
By expanding the search to other cancer types, they also found the
variant gene played a part in multiple myeloma — cancer of the immune
cells — and in throat tumours.
“It influences some of the most fundamental mechanisms controlling
gene activity in our cells,” said Andy Futreal, co-leader of the Cancer
Genome Project at Britain’s Wellcome Trust Sanger Institute, which led
the study.
“Unlike many cancer genes, UTX does not appear to be directly
involved in cell division or cell death but in basic regulation, and
shows the depths to which cancers will plumb in order to get themselves
ready to go.”
Separately, investigators in the United States and Britain identified
several new genetic regions pointing to an enhanced risk for breast
cancer.
Breast cancer is linked to lifestyle and environmental factors, such
as exposure to tobacco smoke, but also has a strong genetic component.
Around half a dozen mutated genes are already closely linked to
vulnerability to breast cancer, most famously the variants of the BRCA-1
and BRCA-2 genes, for which genetic tests are available.
But scientists say the list of culprits is far from complete, given
the complex protein machinery involved in cancer.
Researchers from the US National Institutes of Health (NIH),
meanwhile, said they had uncovered new insights into melanoma, the
deadliest form of skin cancer.
PARIS, AFP |